Kang, J. S. et al. ⦠(2001) 194:1691â7. BAFF binds to 3 receptors that are primarily expressed on B cells: BAFF receptor (BAFF-R), B cell maturation ⦠Organism. Ectopic lymphoid tissues (eLTs) characterized by B cell aggregation contribute to the local immunoglobulin production in nasal polyps (NPs). Doreau A(1), Belot A, Bastid J, Riche B, Trescol-Biemont MC, Ranchin B, Fabien N, Cochat P, Pouteil-Noble C, Trolliet P, Durieu I, Tebib J, Kassai B, Ansieau S, Puisieux A, Eliaou JF, Bonnefoy ⦠Function i GO - Molecular function i. tumor necrosis factor ⦠B-cell survival depends on signals induced by B-cell activating factor (BAFF) binding to its receptor (BAFF-R). Each symbol represents a single sample. Vet ⦠B cell activating factor (BAFF), a member of the tumor necrosis factor family, is a key cytokine for B cell survival, a function that is essential for B cell maturation and memory. "B-Cell Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at ⦠In chronic obstructive pulmonary disease (COPD), lymphoid follicles have been associated with disease severity, and overexpression of BAFF has been demonstrated within lymphoid follicles of ⦠We hypothesized that a rabies virus (RABV) ⦠Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma. This protein acts as a member of the tumor necrosis factor (TNF) family with an essential role in peripheral B-cell homeostasis. B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS), is an important growth factor for B cells. The purpose of this study is to investigate whether BAFF is involved in the B cell ⦠BAFF. BAFF receptor - Wikipedia TACI is currently being targeted for autoimmunity and B cell malignancies via atacicept, a recombinant fusion protein that binds the TACI ligands BAFF and APRIL. Median values are represented by horizontal lines in each series. Schneider P, Takatsuka H, Wilson A, Mackay F, Tardivel A, Lens S, et al. Oryctolagus cuniculus (Rabbit) Status. Citations: Supplier Page Sign In or Register to view pricing. Freshly isolated bursal cells were cultured with ( ) or without ( ) human BAFF recombinant protein (1 µg/ml) for 2â24 h, and viable cells were determined by fluorescenceâactivated cell sorter analysis. Information and translations of b-cell activating factor in the most comprehensive dictionary definitions resource on ⦠B Cell-Activating Factor Receptor (n.). Recent studies have underscored the role of B-cell-activating factor (BAFF), a member of the tumor necrosis factor superfamily, in promoting the survival of malignant B cells, including human multiple myeloma. (AâC) B cell activating factor-receptor (BAFF-R) expression on B cells and B cell subsets in pSS patients at baseline (n = 10) compared with healthy donors (n = 9). Receptors present on a wide variety of hematopoietic and non-hematopoietic cell types that are specific for INTERLEUKIN-4They are involved in signaling a variety of immunological responses related to allergic INFLAMMATION including the differentiation of TH2 CELLS and the ⦠BAFF - B Cell-activating Factor Belonging To The TNF Family; BAFF - B Cell-activating Factor Of The Tumor Necrosis Factor Family; BAFF - Belonging To The Tumor Necrosis Factor Family; BAFF - B-Cell-Activating Factor B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily. BAFF binds to 3 different receptors: BAFF-R, TACI, and BCMA. (PMID: 19383901) Novak AJ ⦠Ansell SM (Cancer research 2009) 3 23 41; No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary ⦠B cellâactivating factors in autoimmune pulmonary alveolar proteinosis Masaki Hirose1, Toru Arai 1, Chikatoshi Sugimoto2, Takayuki Takimoto 2, Reiko Sugawara2, Shojiro Minomo2, Sayoko Shintani2, Naoko Takeuchi 2, Kanako Katayama2, Yasushi Inoue 2, Tomoko Kagawa 2, Takahiko Kasai 3, Masanori Akira4 and Yoshikazu ⦠B-cell activating factor (BAFF) plasma level at the time of chronic GvHD diagnosis is a potential predictor of non-relapse mortality positive regulation of B cell proliferation Source: AgBase "Interferon-gamma and B-cell Activating Factor (BAFF) promote bovine B cell activation independent of TLR9 and T-cell signaling." B cell-activating factor (BAFF) is vital for B cell survival, proliferation, and maturation. Changes in sBCMA levels have been found to correlate with a MM patientâs clinical status in response to treatment. BAFF deficiency leads to an almost complete loss of follicular and marginal zone B lymphocytes in mice ( 12 ). B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene. The cytokine B cell activating factor (BAFF; also known as BLyS) plays an essential role in B cell survival and homeostasis. We here characterized the functional significance of BAFF in the interaction between multiple myeloma and ⦠San Segundo et al., "B-cell-activating factor levels are associated with antibody-mediated histological damage in kidney transplantation," Transplantation Proceedings, vol. Understanding the mechanisms that guide FVIII-specific B cell development could help identify therapeutic targets. 141 , ⦠Bâcellâactivating factor (BAFF) is a shortâterm survival factor for bursal cells. BAFF signals through receptors on B cells, making it an attractive molecule to potentiate vaccine-induced B cell responses. Int Arch. doi: 10.1084/jem.194.11.1691 Analyzing BAFF-R expression and BAFF-binding to B cells in common variable immunodeficiency (CVID) patients, we ⦠This protein is best known for its role in the creation and maintenance of healthy B cells. [5] [6] BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived ⦠B-cell activating factor. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. Unreviewed-Annotation score: -Experimental evidence at transcript level i. In mice, mutations in BAFF or BAFF-R cause B-cell lymphopenia and antibody deficiency. B Cell Activating Factor, Renal Allograft Antibody-Mediated Rejection, and Long-Term Outcome Buchanan R. , Popowych Y. , Dagenais C. , Arsic N. , Mutwiri G.K. , Potter A.A. , Babiuk L.A. , Griebel P.J. Il B-Cell Activating Factor o BAFF, in italiano fattore attivante i linfociti B, anche conosciuto come ligando TNF appartenente alla superfamiglia 13B, è una proteina che negli uomini è codificata dal gene TNFSF13B.Il BAFF è anche conosciuto come uno stimolatore dei linfociti B (BLyS) e ligando espresso sui leuociti correlato con ⦠Gene. B-Cell Activating Factor, BAFF, is a member of the tumor necrosis family, also known as TNF. Compare Product. Various cells can produce BAFF, including antigen-presenting cells, neutrophils, epithelial cells, and activated T lymphocytes. About B-Cell Activating Factor: B-Cell Activating factor is a protein, which is encoded by the human TNFSF13B gene. Published: 08 May 2017 Graft-Versus-Host Disease. 1. The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFF antibody, belimumab, for the therapy of systemic lupus erythematosus. B cell-activating factor is a novel diagnosis parameter for asthma. B cellâactivating factor (BAFF), also known as B lymphocyte stimulator (BLyS) and TNF ligand superfamily member 13B (TNFSF13B), is a cytokine belonging to the TNF ligand family that activates B cells (17, 18). 83. Data are expressed as mean fluorescence intensity (MFI). B-Cell Activating Factor ELISA Kit. B cell activating factor (BAFF) is a member of the tumor necrosis factor (TNF) superfamily of cytokines that links innate with adaptive immunity. , Wilson H.L. Inhibitors to factor VIII (FVIII) remain the most challenging complication of FVIII protein replacement therapy in hemophilia A (HA). The expression levels of BAFF and its potential contribution to B cell maturation remain elusive in patients with tuberculous pleural effusion (TPE). Meaning of b-cell activating factor. Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. B cell activating factor (BAFF) is a pivotal factor for B cell survival, proliferation, and maturation . Rationale: B cellâactivating factor (BAFF) plays a major role in activation of B cells and in adaptive humoral immune responses. Serum B-cell maturation antigen (sBCMA) is the cleaved form of B-cell maturation antigen (BCMA), found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM). B cell Activating Factor/TNFSF13B (Human, Recombinant) is a high quality research product used as highly pure B cell Activating Factor/TNFSF13B (Human, Recombinant) expressed in CHO . B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. B-cell-activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS), is a member of the tumor necrosis factor (TNF) superfamily: TNFSF 13b [48, 49]. J Exp Med. "B-Cell Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at ⦠Allergy Immunol. B-Cell Activating Factor; Detection Range: 78.125-5000pg/mL; Reactivity: Rat; Quantity: 96T; Reviews: Write a Review. B cell activating factor (BAFF) belongs to the tumor necrosis factor (TNF) cytokine family, shown first to play a key role in the maturation and survival of B lymphocytes and in the establishment of the humoral response (8, 9).
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