The antitumor function of tumor necrosis factor (TNF) II. TNF is a multifunctional cytokine with effects on lipid metabolism, coagulation, insulin resistance, and the function of endothelial cells lining blood vessels. )TNF is produced by macrophages when they encounter the poisonous substance in bacteria that is known as endotoxin. It plays an important role in the pathophysiology of several diseases. Tumour necrosis factor (TNF), also called cachectin, a naturally occurring protein that is produced in the human body by the phagocytic cells known as macrophages. (1) TNF-alpha is synthesized as a type II membrane protein, which can be cleaved by a membrane-associated metalloproteinase. Tumor Necrosis Factor (TNF) is a multifunctional cytokine. Tumor necrosis factor-α (TNF-α) is a constituent of the proinflammatory cytokines that is associated with salt-sensitive hypertension (SSH) and related renal injury. As a cytokine, tumor necrosis factor is involved with the inflammatory and immune response and can bind to TNF receptor 1 (TNFR1) or TNF receptor 2 (TNFR2) 10). Tumor necrosis factor: One of multiple proteins capable of inducing necrosis (death) of tumor cells that possess a wide range of proinflammatory actions. Cells release it when they detect a specific substance (an antigen) to which they have become sensitized. Bemelmans MH(1), van Tits LJ, Buurman WA. Elevated angiotensin II (ANG II) and other factors such as oxidative stress conditions promote TNF-α formation. The first two members of the family to be identified were: Tumor Necrosis Factor Alpha (TNF Alpha) and Tumor necrosis factor-beta (TNF-β), also known as Lymphotoxin-alpha, a cytokine that is inhibited by interleukin 10. Tumor necrosis factor: function, release and clearance. a small protein used by the immune system for cell signaling.If macrophages (certain white blood cells) detect an infection, they release TNF in order to alert other cells of the immune system as well as cells of other tissues, leading to inflammation. Tumor Necrosis Factor in the Immune Response . Abbreviated TNF. It plays a part both in acute reactions and systemic inflammation. Tumor necrosis factor (TNF, cachexin, or cachectin; often called tumor necrosis factor alpha or TNF-α) is a cytokine, i.e. It is produced chiefly by activated macrophages, although it can be produced by other cell types as well. The primary role of TNF is in the regulation of immune cells. Tumor necrosis factors (TNF family) refer to a group of cytokines which are mainly secreted by macrophages and can induce cell death of certain tumor cell lines. Tumor necrosis factor (TNF) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. Author information: (1)Department of Surgery, University Hospital Maastricht, The Netherlands. TNFA : Tumor necrosis factor (TNF)-alpha is expressed primarily by activated monocytes as part of the innate immune response to various microbes, gram-negative bacteria in particular. TNF is a natural part of the body's immune response to tumor cells, bacteria, and viruses. (The latter can engulf and destroy bacteria, viruses, and other foreign substances. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma. Tumor necrosis factor occurs in numerous forms, both monomeric and trimeric, as … Tumor necrosis factor function. Tumor Necrosis Factor function TNFα is mainly produced by activated macrophages, T lymphocytes, and natural killer (NK) cells, but is also expressed at lower levels by fibroblasts, smooth muscle cells, and tumor cells. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.